The antidepressant fluoxetine protects the hippocampus from brain damage in experimental pneumococcal meningitis.
RatOthern = 19 fluoxetine-treated and 23 control animalsintraperitoneal10 mg/kg per daystarted 15 min after infection
Model: Pneumococcal meningitis induced by intracisternal infection with live Streptococcus pneumoniae
Significantly fewer fluoxetine-treated animals showed relevant hippocampal apoptosis than littermates (9/19 versus 18/23, P=0.038). A non-significant trend towards less cortical damage was seen (13/19 versus 13/23). Clinical and inflammatory parameters were not affected by fluoxetine.
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