The effect of iloprost and N-acetylcysteine on skeletal muscle injury in an acute aortic ischemia-reperfusion model: an experimental study.
RatIschaemia-reperfusionLimb / skeletal muscleSprague-Dawleymalen = 40 rats randomly divided into four equal groups (10 per gro…intravenous infusion via jugular catheterinfusion initiated during the 1 hour ischaemia period and continued through the…
Model: Acute aortic ischaemia-reperfusion injury of the gastrocnemius muscle produced by clamping the abdominal aorta for 1 hour followed by 2 hours of reperfusion
Total oxidant status, creatine kinase and lactate dehydrogenase were highest in the untreated ischaemia-reperfusion group and lowest in controls; both iloprost and N-acetylcysteine groups had lower levels than untreated ischaemia-reperfusion and higher than controls (P < 0.05). Histopathology showe…
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