Post-trauma administration of the pifithrin-α oxygen analog improves histological and functional outcomes after experimental traumatic brain injury.
RatTBIControlled cortical impactSprague-Dawleymaleintravenous2 mg/kg in vivo; 10 micromolar in vitro5 hours after injury
Model: Controlled cortical impact traumatic brain injury at 4 m/s velocity and 2 mm deformation; parallel in vitro model of primary rat cortical cultures challenged with 50 mM glutamate
PFT-alpha(O) at 10 micromolar enhanced neuronal survival against glutamate cytotoxicity more effectively than PFT-alpha. In vivo, PFT-alpha(O) enhanced functional recovery and decreased contusion volume at 24 h post-injury, reduced p53-positive and phospho-p53-positive neurons in the cortical contu…
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