THERAPY DOSSIER · th-7bf36eee1a56

Pifithrin-alpha oxygen analog (PFT-alpha(O)), compared with pifithrin-alpha (PFT-alpha)

Drug · Pifithrin-alpha oxygen analog (PFT-alpha(O)) is a p53 transcriptional inhibitor (research tool); no confident ChEMBL name match returned

Non-drug Suggest a correction

Evidence & regulatory context

Mechanism: Pifithrin-alpha oxygen analog (PFT-alpha(O)) is a p53 transcriptional inhibitor (research tool); no confident ChEMBL name match returned
Target: Not recorded
Injury models: TBI
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 25819102 ↗2015Reported benefit

Post-trauma administration of the pifithrin-α oxygen analog improves histological and functional outcomes after experimental traumatic brain injury.

RatTBIControlled cortical impactSprague-Dawleymaleintravenous2 mg/kg in vivo; 10 micromolar in vitro5 hours after injury

Model: Controlled cortical impact traumatic brain injury at 4 m/s velocity and 2 mm deformation; parallel in vitro model of primary rat cortical cultures challenged with 50 mM glutamate

PFT-alpha(O) at 10 micromolar enhanced neuronal survival against glutamate cytotoxicity more effectively than PFT-alpha. In vivo, PFT-alpha(O) enhanced functional recovery and decreased contusion volume at 24 h post-injury, reduced p53-positive and phospho-p53-positive neurons in the cortical contu…

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.

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