Can mesenchymal stem cells reverse chronic stress-induced impairment of lung healing following traumatic injury?
RatOtherSprague-DawleyMalen = 6 to 7 rats per groupIntravenousAt the time of lung contusion
Model: Unilateral lung contusion plus chronic restraint stress (2 h restraint on days 1 to 6 after contusion)
Lung injury score fell from 4.4 (2.2) with contusion plus chronic stress to 1.7 (0.8) with mesenchymal stem cells, with an inflammatory cell subscore of zero, and regulatory T cells rose from 6.2% (1.3) to 12.9% (2.4).
Extraction: extract · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.