Nrf2 Activation Protects against Solar-Simulated Ultraviolet Radiation in Mice and Humans.
MouseRadiationSKH-1 hairless; C57BL/6; Nrf2 knockout and constitutively active Nrf2 miceFemaleTopical40 nmol TBE-31 per topical application in mice
Model: Chronic solar-simulated ultraviolet radiation exposure of skin (cutaneous tumour formation in mice; acute erythema in healthy human volunteers)
Genetic or pharmacological Nrf2 activation lowered tumour incidence, multiplicity and burden and reduced pro-inflammatory gene expression in mice, and topical sulforaphane reduced ultraviolet-induced erythema in healthy human subjects.
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