Effect of pregabalin in preventing secondary damage in traumatic brain injury: an experimental study.
RatTBIUnspecifiedSprague-DawleyMalen = 40 rats randomised into 4 equal groups (10 per group)
Model: Experimental head trauma
The trauma-only group had significantly higher oedema and neuronal damage scores than the other groups, and inflammation was significantly more prevalent in the trauma group than in the control and trauma plus pregabalin groups, indicating anti-oedema, anti-inflammatory and neuroprotective effects.
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