THERAPY DOSSIER · th-bfedbbcb4f84

Pregabalin

Drug · Voltage-gated calcium channel modulator (MODULATOR); binds the alpha2delta-1 auxiliary subunit

No trauma translation Suggest a correction

This record is classified as “NO TRAUMA TRANSLATION”. Read the indication and notes below for the specific context.

Evidence & regulatory context

Mechanism: Voltage-gated calcium channel modulator (MODULATOR); binds the alpha2delta-1 auxiliary subunit
Target: CHEMBL2363032
Injury models: TBI
Reported indication: Not recorded
First approval: 2004
Development stage: Not recorded
ChEMBL record: CHEMBL1059 ↗
ChEMBL max phase: 4 / 4 (development scale, not regulatory approval)
Synonyms: Pregabalin; Lyrica; CI-1008; PD-144723; Alzain; Axalid; Lecaent; Rewisca; Bonqat
Note: Not recorded

Clinical trials 7

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT02374567 ↗PHASE3terminated

Pharmacovigilance in Gerontopsychiatric Patients

Dementia · Depression · Schizophrenia · Psychosomatic Disorders · Anxiety Disorders

Enrolment: 407 · Results not recorded

NCT00905437 ↗PHASE3terminated

Pregabalin Versus Placebo Adjunct to Standard of Care in Total Hip Arthroplasty

Pain, Perioperative

Enrolment: 72 · Results not recorded

NCT00830167 ↗PHASE3completed

Pregabalin (CI-1008) in the Treatment of Fibromyalgia

Fibromyalgia

Enrolment: 498 · Results not recorded

NCT02215252 ↗PHASE2completed

PF-05089771 Monotherapy and Add-on to Pregabalin in Painful Diabetic Peripheral Neuropathy

Diabetic Neuropathy, Painful

Enrolment: 141 · Results not recorded

NCT06600607 ↗EARLY_PHASE1completed

Pharmacodynamic Effects of Pregabalin in Healthy Male Adults

Pain Detection · Pain Threshold

Enrolment: 20 · Results not recorded

NCT01614236 ↗NAunknown

Pre- Versus Post-Incisional Pregabalin for Postoperative Pain Control

Postoperative Pain Control · Multimodal Analgesia

Enrolment: 100 · Results not recorded

NCT01321801 ↗NAcompleted

Preoperative Use of Pregabalin and Analgesia Levels After Laparoscopic Cholecystectomy

Pain Postoperative

Enrolment: 50 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 25785578 ↗2015Reported benefit

Effect of pregabalin in preventing secondary damage in traumatic brain injury: an experimental study.

RatTBIUnspecifiedSprague-DawleyMalen = 40 rats randomised into 4 equal groups (10 per group)

Model: Experimental head trauma

The trauma-only group had significantly higher oedema and neuronal damage scores than the other groups, and inflammation was significantly more prevalent in the trauma group than in the control and trauma plus pregabalin groups, indicating anti-oedema, anti-inflammatory and neuroprotective effects.

Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.

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