Sodium selenate reduces hyperphosphorylated tau and improves outcomes after traumatic brain injury.
RatTBIFluid percussionLong-EvansMalen = 90 ratsSubcutaneous osmotic pumpCommenced after injury
Model: Lateral fluid percussion injury with sham-injury controls; human post-mortem acute traumatic brain injury brain samples
Injury acutely reduced PR55 expression and protein phosphatase 2A activity and raised phosphorylated tau; 12 weeks of sodium selenate increased protein phosphatase 2A activity and PR55 expression, reduced the phosphorylated to total tau ratio, attenuated brain damage and improved behavioural outcom…
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