Angiotensin-converting enzyme inhibition attenuates lipopolysaccharide-induced lung injury by regulating the balance between angiotensin-converting enzyme and angiotensin-converting enzyme 2 and inhibiting mitogen-activated protein kinase activation.
RatEndotoxin/LPSSprague-DawleyMaleIntraperitoneal in vivo50 mg/kg in vivo; 10 mol/mL in vitro as printed in the sour…30 min before lipopolysaccharide administration
Model: Lipopolysaccharide-induced acute lung injury (7.5 mg/kg lipopolysaccharide intravenously); rat pulmonary microvascular endothelial cells stimulated with lipopolysaccharide in vitro
Captopril pretreatment attenuated lung pathology, reduced tumour necrosis factor-alpha and interleukin-6, lowered the angiotensin II to angiotensin-1-7 ratio and reduced the ACE to ACE2 ratio from 7.07 to 1.71 in vivo and 5.18 to 1.52 in vitro, with inhibition of p38 MAPK, ERK1/2 and JNK phosphoryl…
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