PREVENTION OF RADIATION-INDUCED RETINOPATHY WITH AMIFOSTINE IN WISTAR ALBINO RATS.
RatRadiationWistar albinoFemalen = 108 rats in total (48 apoptosis, 40 acute effects, 20 late…Intraperitoneal260 mg/kg30 min before irradiation
Model: Single 20 Gy whole-cranium irradiation
Apoptosis increased significantly at 12 h in the radiotherapy arm (p=0.029) and was lower with amifostine across the three time points (p=0.008), and late electron microscopic damage scores were lower with amifostine (p<0.001).
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