Estrogen modulates 7/4 antigen distribution within eccentrically contracted injured skeletal muscle.
MouseOtherC57BL/6Femalen = 48 mice purchased; 27 oestrogen-positive and 19 oestrogen-n…Subcutaneous slow-release pellet21-day release pellets containing 0.05 mg 17-beta-oestradio…Pellets implanted before injury, with the eccentric contraction protocol starte…
Model: Eccentric contraction injury of the left plantar flexor muscles in ovariectomised mice using a servomotor, three bouts of 150 trials with electrically stimulated isometric contraction followed by forced stretch
At 48 h after eccentric contraction injury, oestrogen-positive mice had more 7/4-positive and Ly6C/G-positive myofibres, a greater 7/4 area percentage and more 7/4-positive connective tissue cells than oestrogen-negative mice. Time to fatigue did not differ between groups, indicating comparable ini…
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