A synthetic fibrin cross-linking polymer for modulating clot properties and inducing hemostasis.
RatHaemorrhage/shockControlledSprague-Dawleyn = 5 rats per treatment group across five groups (25 total)Intravenous, via jugular vein catheter15 mg/kg as a 10 mg/mL solutionImmediately after clamp release at the onset of bleeding
Model: Femoral artery injury with controlled haemorrhage and saline resuscitation: 3 mm longitudinal arteriotomy, catheter bleeds to set starting blood pressure at 40 to 50 mmHg, free bleeding for 15 min, then saline at 3 mL/min/kg to hold blood pressure above 60 mmHg up to 60 mL/kg
All PolySTAT-treated rats survived the protocol compared with 0 to 40 per cent for saline, PolySCRAM, albumin and factor XIIIa controls, with no rebleeding and up to eleven-fold less blood loss. PolySTAT rats needed about five-fold less saline (42 plus or minus 17 per cent of the maximum allowed vo…
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