THERAPY DOSSIER · th-54f16e5ba32c

PolySTAT, a synthetic fibrin cross-linking polymer

Drug · ChEMBL not queried: PolySTAT is a synthetic peptide-functionalised haemostatic polymer, not a defined ChEMBL small molecule. ClinicalTrials.gov query 'PolySTAT OR fibrin cross-linking polymer' returned 0 hits, an explicit searched negative result. No human trial.

Non-drug Suggest a correction

Evidence & regulatory context

Mechanism: ChEMBL not queried: PolySTAT is a synthetic peptide-functionalised haemostatic polymer, not a defined ChEMBL small molecule. ClinicalTrials.gov query 'PolySTAT OR fibrin cross-linking polymer' returned 0 hits, an explicit searched negative result. No human trial.
Target: Not recorded
Injury models: Haemorrhage/shock
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 25739763 ↗2015Reported benefit

A synthetic fibrin cross-linking polymer for modulating clot properties and inducing hemostasis.

RatHaemorrhage/shockControlledSprague-Dawleyn = 5 rats per treatment group across five groups (25 total)Intravenous, via jugular vein catheter15 mg/kg as a 10 mg/mL solutionImmediately after clamp release at the onset of bleeding

Model: Femoral artery injury with controlled haemorrhage and saline resuscitation: 3 mm longitudinal arteriotomy, catheter bleeds to set starting blood pressure at 40 to 50 mmHg, free bleeding for 15 min, then saline at 3 mL/min/kg to hold blood pressure above 60 mmHg up to 60 mL/kg

All PolySTAT-treated rats survived the protocol compared with 0 to 40 per cent for saline, PolySCRAM, albumin and factor XIIIa controls, with no rebleeding and up to eleven-fold less blood loss. PolySTAT rats needed about five-fold less saline (42 plus or minus 17 per cent of the maximum allowed vo…

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.

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