The triterpenoid RTA 408 is a robust mitigator of hematopoietic acute radiation syndrome in mice.
MouseRadiationC57BL/6 (congenic CD45.1 and CD45.1/CD45.2 recipients for transplantation)Intraperitoneal17.5 mg/kgStarting 24 h after irradiation
Model: Total body X-irradiation at 7, 7.5 or 8 Gy (250 kVp, 2 mm copper filter, about 1.4 Gy/min); transplant recipients received 7.5 Gy at about 1.36 Gy/min
RTA 408 given at 24, 48 and 72 h after irradiation gave 35-day survival of 100 per cent at 7 Gy and 60 per cent at 7.5 Gy, whereas no vehicle-treated mice survived 7.5 Gy; the 40 per cent survival at 8 Gy was not significant. Blood counts and bone marrow cellularity normalised by 11 to 14 weeks, an…
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