Phase 3 omaveloxolone (BIIB141) in Friedreich's Ataxia aged 2 to <16 years
Friedreich Ataxia
Enrolment: 255 · Results not recorded
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Drug · Nrf2 (NFE2L2) activator (ACTIVATOR), direct interaction
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Friedreich Ataxia
Enrolment: 255 · Results not recorded
Inflammation and Pain Following Ocular Surgery
Enrolment: 109 · Results not recorded
Friedreich Ataxia
Enrolment: 172 · Results not recorded
Breast Cancer
Enrolment: 187 · Results not recorded
Mitochondrial Myopathies
Enrolment: 53 · Results not recorded
Healthy Adult Subjects
Enrolment: 20 · Results not recorded
Healthy Male Subjects
Enrolment: 8 · Results not recorded
Healthy Volunteer
Enrolment: 12 · Results not recorded
Friedreich Ataxia
Enrolment: 10 · Results not recorded
Friedreich's Ataxia
Enrolment: 30 · Results not recorded
1 studies reported at therapy level; 1 evidence entries itemised.
Model: Total body X-irradiation at 7, 7.5 or 8 Gy (250 kVp, 2 mm copper filter, about 1.4 Gy/min); transplant recipients received 7.5 Gy at about 1.36 Gy/min
RTA 408 given at 24, 48 and 72 h after irradiation gave 35-day survival of 100 per cent at 7 Gy and 60 per cent at 7.5 Gy, whereas no vehicle-treated mice survived 7.5 Gy; the 40 per cent survival at 8 Gy was not significant. Blood counts and bone marrow cellularity normalised by 11 to 14 weeks, an…
Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.