Protective effects of rosuvastatin in a rat model of lung contusion: Stimulation of the cyclooxygenase 2-prostaglandin E-2 pathway.
RatOtherMaleAdministered immediately after trauma
Model: Blunt chest injury producing lung contusion in rats
Rosuvastatin significantly decreased cytokine levels raised by blunt chest trauma and increased iNOS, COX-2, haem oxygenase-1 and prostaglandin E2 in bronchoalveolar lavage fluid. Co-administration of meloxicam prevented these changes, indicating that the prostaglandin pathway mediates the statin e…
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