Smoke inhalation injury repaired by a bone marrow-derived mesenchymal stem cell paracrine mechanism: Angiogenesis involving the Notch signaling pathway.
RatChemical/toxinSprague-DawleyMaleIntravenous, tail vein injection2 x 10^6 cells in 5 mL phosphate-buffered salineAfter establishment of smoke inhalation injury
Model: Smoke inhalation acute lung injury in rats
Systemic transplantation of preconditioned bone marrow-derived mesenchymal stem cells significantly increased pulmonary microvessel numbers, improved the lung wet to dry weight ratio and alleviated lung injury through paracrine activity. Notch1 protein expression increased significantly after trans…
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