THERAPY DOSSIER · th-d9384ab88970

Bone marrow-derived mesenchymal stem cells preconditioned by 60Co gamma-ray irradiation

Biologic

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Chemical/toxin
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 6

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT02943889 ↗PHASE1/PHASE2unknown

Bone-marrow Derived Stem Cell Transplantation in Decompensated Liver Cirrhosis

Liver Cirrhosis

Enrolment: 40 · Results not recorded

NCT03692221 ↗EARLY_PHASE1withdrawn

Percutaneous Image Guided Delivery of Autologous BM-MSC for Symptomatic Degenerated Intervertebral Disc Disease

Disc Degeneration

Enrolment: 0 · Results not recorded

NCT06798064 ↗Phase not recordedno longer available

Expanded Access Using Allogeneic Bone-marrow Derived Human Mesenchymal Stem Cells for a Parkinson's Disease Subject

Parkinson Disease

Enrolment not recorded · Results not recorded

NCT06752577 ↗Phase not recordedrecruiting

Safety and Tolerability of Vertebral Bone Marrow-derived MSC in Chronic Kidney Disease

Chronic Kidney Diseases · Kidney Transplant

Enrolment: 75 · Results not recorded

NCT07431008 ↗Phase not recordedrecruiting

Safety Follow-up of Cellgram-ED (Autologous BM-MSC) in Post-Radical Prostatectomy Erectile Dysfunction

Erectile Dysfunction

Enrolment: 32 · Results not recorded

NCT06822686 ↗NAwithdrawn

Autologous BM-MSC in the Management of Fistulating Perianal Crohn's Disease

Fistula in Ano · Crohn Disease

Enrolment: 0 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 25710428 ↗2015Reported benefit

Smoke inhalation injury repaired by a bone marrow-derived mesenchymal stem cell paracrine mechanism: Angiogenesis involving the Notch signaling pathway.

RatChemical/toxinSprague-DawleyMaleIntravenous, tail vein injection2 x 10^6 cells in 5 mL phosphate-buffered salineAfter establishment of smoke inhalation injury

Model: Smoke inhalation acute lung injury in rats

Systemic transplantation of preconditioned bone marrow-derived mesenchymal stem cells significantly increased pulmonary microvessel numbers, improved the lung wet to dry weight ratio and alleviated lung injury through paracrine activity. Notch1 protein expression increased significantly after trans…

Extraction: extract · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.

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