Effects of Therapeutic Hypothermia on Apoptosis and Autophagy After Spinal Cord Injury in Rats.
RatSpinal cord injuryContusionSprague-DawleyMaleStarted immediately after induction of spinal cord injury
Model: Contusion of the spinal cord at the ninth thoracic vertebra using a 25 g/cm impact
Both hypothermia and methylprednisolone significantly reduced cleaved caspase-8, -9 and -3 at 2 days after injury, and hypothermia also reduced LC3II and Beclin-1 expression, with fewer TUNEL and LC3-positive cells at 2 and 7 days. Basso-Beattie-Bresnahan scores were significantly higher at 6 weeks…
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