THERAPY DOSSIER · th-01aa32219f17

Moderate systemic therapeutic hypothermia, compared with high-dose methylprednisolone sodium succinate

Procedure

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Spinal cord injury
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 3

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT01545271 ↗PHASE1/PHASE2completed

Xenon and Cooling Therapy in Babies at High Risk of Brain Injury

Hypoxic Ischaemic Encephalopathy

Enrolment: 32 · Results not recorded

NCT07526649 ↗NAnot yet recruiting

Head Cooling in Ischaemic Stroke Patients Undergoing Endovascular Thrombectomy (COOLHEAD-2b)

Acute Ischemic Stroke

Enrolment: 182 · Results not recorded

NCT02683915 ↗Phase not recordedcompleted

Acute Kidney Injury in Asphyxiated Infants Treated by Therapeutic Hypothermia

Hypoxic Ischemic Encephalopathy

Enrolment: 30 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 25705963 ↗2015Reported benefit

Effects of Therapeutic Hypothermia on Apoptosis and Autophagy After Spinal Cord Injury in Rats.

RatSpinal cord injuryContusionSprague-DawleyMaleStarted immediately after induction of spinal cord injury

Model: Contusion of the spinal cord at the ninth thoracic vertebra using a 25 g/cm impact

Both hypothermia and methylprednisolone significantly reduced cleaved caspase-8, -9 and -3 at 2 days after injury, and hypothermia also reduced LC3II and Beclin-1 expression, with fewer TUNEL and LC3-positive cells at 2 and 7 days. Basso-Beattie-Bresnahan scores were significantly higher at 6 weeks…

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.

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