Salvianolic acids attenuate rat hippocampal injury after acute CO poisoning by improving blood flow properties.
RatChemical/toxinSprague-DawleyMalen = Carbon monoxide alone n = 15; control, salvianolic acid and…Intravenous, tail vein6 mg/kg per day; comparator 20 per cent mannitol at 10 mL/k…Started after carbon monoxide exposure
Model: Acute carbon monoxide poisoning by exposure to 3000 ppm carbon monoxide in a chamber at 8 L/min for 40 min, producing more than 70 per cent carboxyhaemoglobin
Salvianolic acid preserved hippocampal CA1 neurons (72 plus or minus 9 surviving neurons per field versus 58 plus or minus 10 with carbon monoxide alone, and not different from controls), whereas neuron density fell by 29 per cent with carbon monoxide and 63 per cent with mannitol. It also prevente…
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