Protective effects of caffeic acid phenethyl ester against acute radiation-induced hepatic injury in rats.
RatRadiationSprague-DawleyMaleIntraperitoneal30 mg/kgPretreatment for 3 consecutive days before irradiation
Model: Single 30 Gy beta-ray irradiation to the upper abdomen producing acute hepatic injury
Pretreatment significantly decreased serum alanine and aspartate aminotransferase and increased superoxide dismutase and glutathione activity, with histology confirming protection against radiation hepatotoxicity. Hepatocyte apoptosis was inhibited and NF-kappaB p65 nuclear transport, TNF-alpha, ni…
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