Early applied electric field stimulation attenuates secondary apoptotic responses and exerts neuroprotective effects in acute spinal cord injury of rats.
RatSpinal cord injuryUnspecifiedSprague-DawleyFemaleApplied immediately after injury
Model: Acute spinal cord injury following laminectomy, with injury potential monitored between intact and injured cord ends
Stimulated rats showed significantly better locomotor recovery, less myelin loss and larger and more numerous myelinated fibres in the dorsal corticospinal tract at 8 weeks. Stimulation inhibited calpain, caspase-3 and Bax and reduced apoptotic cells within 4 weeks of injury.
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