THERAPY DOSSIER · th-d4691370fabe

Applied electric field stimulation with the cathode distal to the lesion

Device

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Spinal cord injury
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 1

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT06712992 ↗NAactive not recruiting

Effect of trans-spinal direct current stimulation in the management of non-specific chronic low back pain

Low Back Pain

Enrolment: 40 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 25701712 ↗2015Reported benefit

Early applied electric field stimulation attenuates secondary apoptotic responses and exerts neuroprotective effects in acute spinal cord injury of rats.

RatSpinal cord injuryUnspecifiedSprague-DawleyFemaleApplied immediately after injury

Model: Acute spinal cord injury following laminectomy, with injury potential monitored between intact and injured cord ends

Stimulated rats showed significantly better locomotor recovery, less myelin loss and larger and more numerous myelinated fibres in the dorsal corticospinal tract at 8 weeks. Stimulation inhibited calpain, caspase-3 and Bax and reduced apoptotic cells within 4 weeks of injury.

Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.

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