Normobaric oxygen worsens outcome after a moderate traumatic brain injury.
RatTBIControlled cortical impactSprague-DawleyMalen = 8 per group (normobaric oxygen n = 8, air n = 8)InhaledAdministered acutely after injury
Model: Controlled cortical impact producing a moderate traumatic brain injury to the primary forelimb somatosensory cortex
Normobaric oxygen increased lesion volume in this moderate traumatic brain injury model and had no positive effect on behavioural measures. The authors concluded that the results do not support acute normobaric oxygen use in patients with moderate traumatic brain injury.
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