THERAPY DOSSIER · th-10b33dd75c66

Normobaric oxygen

Procedure · Procedure (normobaric oxygen/hyperoxia); not a ChEMBL entity

Evidence & regulatory context

Mechanism: Procedure (normobaric oxygen/hyperoxia); not a ChEMBL entity
Target: Not recorded
Injury models: TBI
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 2

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT05965687 ↗PHASE3completed

Normobaric Hyperoxia Combined With IV Thrombolysis for Acute Ischemic Stroke (OPENS-3)

Acute Ischemic Stroke

Enrolment: 1230 · Results not recorded

NCT03500939 ↗PHASE2terminated

Penumbral Rescue by Normobaric Oxygen Administration in Ischemic Stroke

Acute Ischemic Stroke

Enrolment: 223 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 25690469 ↗2015Reported harm

Normobaric oxygen worsens outcome after a moderate traumatic brain injury.

RatTBIControlled cortical impactSprague-DawleyMalen = 8 per group (normobaric oxygen n = 8, air n = 8)InhaledAdministered acutely after injury

Model: Controlled cortical impact producing a moderate traumatic brain injury to the primary forelimb somatosensory cortex

Normobaric oxygen increased lesion volume in this moderate traumatic brain injury model and had no positive effect on behavioural measures. The authors concluded that the results do not support acute normobaric oxygen use in patients with moderate traumatic brain injury.

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.

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