Daily acute intermittent hypoxia elicits functional recovery of diaphragm and inspiratory intercostal muscle activity after acute cervical spinal injury.
RatSpinal cord injuryHemisection / partialSprague-DawleyMalen = 32 rats: daily hypoxia plus KW6002 n = 8, daily hypoxia plu…Inhaled hypoxia via gas chamber; KW6002 by intraperitoneal injectionTen 5-min episodes of 10.5 per cent oxygen with 5-min normo…Treatment started 7 days after hemisection, with drug or vehicle given 5 min be…
Model: Left C2 cervical spinal hemisection after dorsal laminectomy, with reconstructed lesion area 45.4 to 51.0 per cent of the spinal cross-sectional area
Three days after the daily exposures, tidal volume was greater than in time controls in room air (0.47 plus or minus 0.01 versus 0.40 plus or minus 0.01 mL/100 g, p < 0.05) and at maximum chemoreceptor stimulation (0.83 plus or minus 0.01 versus 0.73 plus or minus 0.01 mL/100 g, p < 0.001), driven…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.