Sodium Butyrate Reduces Organ Injuries in Mice with Severe Acute Pancreatitis Through Inhibiting HMGB1 Expression.
MouseChemical/toxinSprague-Dawley (reported as mice by the authors)Femalen = 48 animals per group across three groups, euthanised at 0,…
Model: L-arginine-induced severe acute pancreatitis, two intraperitoneal injections of 20% L-arginine (200 mg/g)
Sodium butyrate improved pancreatic histopathology, lowered serum amylase, and reduced serum HMGB1, TNF-alpha and IL-6, HMGB1 mRNA and NF-kappaB activity relative to untreated severe acute pancreatitis animals.
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