Impact of beta-adrenoceptor blockade on systemic inflammation and coagulation disturbances in rats with acute traumatic coagulopathy.
RatHaemorrhage/shockControlledSprague-DawleyMalen = n=10 per group in ATCB and ATCC and n=5 in sham at each tim…Intraperitoneal7.5 mg/kgAt baseline, before trauma and haemorrhagic shock (pre-treatment)
Model: Acute traumatic coagulopathy induced by 6 cm laparotomy plus bilateral femur fractures and haemorrhagic shock to a mean arterial pressure of 35 to 40 mmHg (about 40% blood volume removed) maintained for 1 h
Propranolol preserved heart rate variability and reduced TNF-alpha, IL-6, plasmin-antiplasmin complex, tissue plasminogen activator, soluble thrombomodulin, syndecan-1 and hepatic NF-kappaB expression, but did not alter prothrombin time, activated partial thromboplastin time, thrombin-antithrombin…
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