Tacrolimus prevents laryngotracheal stenosis in an acute-injury rat model.
RatWoundSprague-DawleyMaleIntramuscular0.2 mg/kg or 1.0 mg/kgStarted after scraping injury
Model: Laryngotracheal mucosal scrape injury with a nylon brush through a tracheostoma, producing acquired stenosis
Low-dose tacrolimus at 0.2 mg/kg significantly reduced airway stenosis at tracheal and cricoid levels versus untreated animals, with downregulation of nuclear factor of activated T cells and interleukin 2 in submucosal fibroblasts, neovascular cells and glandular cells. The higher 1.0 mg/kg dose ha…
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