Early intervention for spinal cord injury with human induced pluripotent stem cells oligodendrocyte progenitors.
RatSpinal cord injuryContusionLewisFemalen = n=12 rats per treatmentIntraspinal injection500,000 live iPS-OPs in 2 microlitres of phosphate buffered…24 h after contusion injury
Model: Moderate contusive spinal cord injury at thoracic vertebra T8 after laminectomy, using a Multicenter Animal Spinal Cord Injury Study impactor
Grafted cells survived about two months, with more than 70% differentiating into mature myelin-expressing oligodendrocytes. Transplantation increased myelinated axon numbers, produced an approximately fivefold reduction in cavity size and reduced glial scarring versus heat-killed controls, with imp…
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