A Phase 1/2a Dose Escalation Study of AST-OPC1 in Subjects With Subacute Cervical Spinal Cord Injury
Cervical Spinal Cord Injury · Spinal Cord Trauma
Enrolment: 25 · Results not recorded
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Biologic
2 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Cervical Spinal Cord Injury · Spinal Cord Trauma
Enrolment: 25 · Results not recorded
Spinal Cord Injury
Enrolment: 10 · Results not recorded
Demyelinating Diseases
Enrolment: 5 · Results not recorded
1 studies reported at therapy level; 1 evidence entries itemised.
Model: Moderate contusive spinal cord injury at thoracic vertebra T8 after laminectomy, using a Multicenter Animal Spinal Cord Injury Study impactor
Grafted cells survived about two months, with more than 70% differentiating into mature myelin-expressing oligodendrocytes. Transplantation increased myelinated axon numbers, produced an approximately fivefold reduction in cavity size and reduced glial scarring versus heat-killed controls, with imp…
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