Neuroinflammation and neuronal autophagic death were suppressed via Rosiglitazone treatment: New evidence on neuroprotection in a rat model of global cerebral ischemia.
RatIschaemia-reperfusionCerebral (MCAO/stroke)Sprague-DawleyFemaleInjection (route not specified in the abstract)Immediately following global cerebral ischaemia
Model: Global cerebral ischaemia with reperfusion
A single injection of rosiglitazone immediately after global cerebral ischaemia reduced infarct volume and brain oedema, increased neuronal survival and functional recovery, and lowered inflammatory cytokines and autophagy-associated proteins in hippocampus.
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