Ebselen Attenuates Lung Injury in Experimental Model of Carrageenan-Induced Pleurisy in Rats.
RatChemical/toxinWistarMaleIntragastric50 mg/kgAfter carrageenan administration
Model: Carrageenan-induced pleurisy, 2% lambda-carrageenan into the pleural cavity
Ebselen inhibited leukocyte influx, myeloperoxidase activity and nitrite/nitrate concentration, with anti-inflammatory activity similar to dexamethasone and greater antioxidant activity.
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