SPI-1005 in Adults Receiving a Cochlear Implant
Hearing Loss · Cochlear Trauma
Enrolment: 40 · Results not recorded
Loading the evidence…
Drug · Antioxidant (glutathione peroxidase mimetic); no target_chembl_id assigned in ChEMBL
1 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Hearing Loss · Cochlear Trauma
Enrolment: 40 · Results not recorded
Meniere's Disease
Enrolment: 200 · Results not recorded
Meniere Disease
Enrolment: 220 · Results not recorded
Bipolar Disorder
Enrolment: 60 · Results not recorded
Ototoxicity
Enrolment: 35 · Results not recorded
COVID-19
Enrolment: 25 · Results not recorded
COVID-19
Enrolment: 60 · Results not recorded
Hearing Loss · Ototoxicity
Enrolment: 0 · Results not recorded
Meniere's Disease
Enrolment: 40 · Results not recorded
Treatment-Resistant Depression
Enrolment: 50 · Results not recorded
3 studies reported at therapy level; 3 evidence entries itemised.
Model: Acute spinal cord injury
Ebselen increased the BBB locomotor score, raised glutathione, superoxide dismutase and catalase, increased mitochondrial ATP and Na-K-ATPase activity, reduced cytochrome c and Smac release and reduced apoptosis after spinal cord injury.
Extraction: extract · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.
Model: Carrageenan-induced pleurisy, 2% lambda-carrageenan into the pleural cavity
Ebselen inhibited leukocyte influx, myeloperoxidase activity and nitrite/nitrate concentration, with anti-inflammatory activity similar to dexamethasone and greater antioxidant activity.
Extraction: extract · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.
Model: Modified weight-drop traumatic brain injury
Ebselen significantly ameliorated neurological injury in a dose-dependent manner, lowering neurological severity score, brain water content and histopathological damage, and reduced nitric oxide and iNOS mRNA while inhibiting TLR4 and phosphorylated p38 MAPK expression.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.