Prolylhydroxylase and collagenase activities in the healing of acetic acid-induced gastric ulcers in rats and the effects of cimetidine and elcatonin.
RatChemical/toxinInbred strain not specifiedMaleDuring the ulcer healing phase
Model: Gastric ulcer induced by subserosal acetic acid injection, confirmed endoscopically on day 3
Collagenase activity rose at the acute ulcer stage while prolylhydroxylase rose during healing. Cimetidine did not alter prolylhydroxylase but tended to increase collagenase activity, whereas elcatonin increased prolylhydroxylase with little effect on collagenase.
Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.