The hydrocortisone protection of glycocalyx on the intestinal capillary endothelium during severe acute pancreatitis.
RatChemical/toxinSprague-DawleyMale
Model: Severe acute pancreatitis induced by pancreatic duct injection of sodium taurocholate
Glycocalyx degradation appeared 3 h after onset of severe acute pancreatitis and intestinal perfusion fell significantly by 12 h, in parallel with raised superior mesenteric vein TNF-alpha. Hydrocortisone improved intestinal perfusion and reduced glycocalyx degradation.
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