The effects of insulin-like growth factor-1 gene therapy and cell transplantation on rat acute wound model.
RatWoundWistarMalen = 15 rats in total, 5 per group across three groupsIntradermal injection around the wound at four different sitesAt the time of wounding, 24 h after cell transfection
Model: Full-thickness square skin wound 1.5 x 1.5 cm on the dorsum, down to the panniculus carnosus
IGF-1 expression peaked at 96.95 pg/mL at 24 h after transfection compared with 16.9 pg/mL in controls. On day 7 the transfected fibroblast group had greater epidermal width (86.8 plus or minus 6.76 micrometres) than native fibroblasts (76.2 plus or minus 2.28) and saline (54.4 plus or minus 3.5),…
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