THERAPY DOSSIER · th-9f1c552da67e

Allogeneic dermal fibroblasts transfected with rat IGF-1 cDNA using Lipofectamine 2000

Other

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Wound
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 25558384 ↗2014Reported benefit

The effects of insulin-like growth factor-1 gene therapy and cell transplantation on rat acute wound model.

RatWoundWistarMalen = 15 rats in total, 5 per group across three groupsIntradermal injection around the wound at four different sitesAt the time of wounding, 24 h after cell transfection

Model: Full-thickness square skin wound 1.5 x 1.5 cm on the dorsum, down to the panniculus carnosus

IGF-1 expression peaked at 96.95 pg/mL at 24 h after transfection compared with 16.9 pg/mL in controls. On day 7 the transfected fibroblast group had greater epidermal width (86.8 plus or minus 6.76 micrometres) than native fibroblasts (76.2 plus or minus 2.28) and saline (54.4 plus or minus 3.5),…

Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.

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