I-FABP as biomarker for the early diagnosis of acute mesenteric ischemia and resultant lung injury.
MouseIschaemia-reperfusionIntestinal / mesentericC57BL/6Malen = NAC experiment: 3 sham, 4 no-NAC and 4 NAC animals. Ischaem…Intraperitoneal300 mg/kgPretreatment before ischaemia and reperfusion
Model: Acute mesenteric ischaemia by superior mesenteric artery occlusion for 0.5 to 3 h followed by 2 h reperfusion, with resultant lung injury
NAC pretreatment significantly lowered plasma I-FABP at 2 h ischaemia, reduced intestinal alpha-defensins, and significantly reduced lung myeloperoxidase and TNF-alpha at 1 h ischaemia, with a non-significant reduction in lung IL-1 beta at 2 h. Effects were less marked at 2 and 3 h of ischaemia.
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