A pharmacologic approach to vagal nerve stimulation prevents mesenteric lymph toxicity after hemorrhagic shock.
RatHaemorrhage/shockControlledSprague-DawleyMaleIntravenous1 mg/kgGiven after the haemorrhagic shock phase in the trauma/haemorrhagic shock cohort
Model: Laparotomy plus 60 minutes of haemorrhagic shock (mean arterial pressure 35 mm Hg) followed by fluid resuscitation; sham controls
CPSI-121 increased efferent vagal discharge without altering blood pressure, prevented trauma and haemorrhagic shock induced gut and lung injury, and attenuated mesenteric lymph mediated neutrophil priming.
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