Ethyl pyruvate protects against blood-brain barrier damage and improves long-term neurological outcomes in a rat model of traumatic brain injury.
RatTBIControlled cortical impactSprague-DawleyMalen = n=10 per group for behaviour, histology and dose-finding; n…Intraperitoneal30 mg/kg (dose-finding used 10, 30 and 50 mg/kg)First dose 15 minutes after controlled cortical impact
Model: Unilateral controlled cortical impact, 5 mm flat tip, 3.2 mm depth, 0.5 s dwell, 4.0 m/s velocity, via 5.4 mm right parietal craniotomy; sham craniotomy controls
Ethyl pyruvate 30 mg/kg improved sensorimotor and cognitive performance and reduced tissue loss to 28 days, and at 48 hours reduced blood-brain barrier permeability, oedema, MMP-9 activity, tight junction degradation and neuroinflammation.
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