Acute suppression of TGF-beta with local, sustained release of tranilast against the formation of fibrous capsules around silicone implants.
RatOtherSprague-DawleyMaleLocal sustained release from the implant surfaceFrom the time of implantation
Model: Subcutaneous silicone implant placement provoking foreign body reaction and fibrous capsule formation over 12 weeks
Early local tranilast release significantly reduced capsule thickness and collagen density at 12 weeks, with fewer differentiated macrophages and less TGF-beta and fibroblast accumulation.
Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.