Biphasic bisperoxovanadium administration and Schwann cell transplantation for repair after cervical contusive spinal cord injury.
RatSpinal cord injuryContusionSprague-Dawley (GFP-expressing transgenic Sprague-Dawley donors for Schwann cells)Femalen = 34 rats allocated: sham 6, vehicle 6, bpV 6, Schwann cells…bpV(pic) intraperitoneal; Schwann cells stereotaxic intraspinal injection into the lesion epicentre at 1.2 mm depth400 micrograms/kg/day bpV(pic) stated in the methods (the a…bpV(pic) immediately after injury and at 2 hours; Schwann cells transplanted 7…
Model: Right unilateral C5 hemicontusion using the NYU/MASCIS impactor, 2.5 mm tip, 10 g weight, 12.5 mm drop height, measured displacement 2.02 plus or minus 0.21 mm and velocity 0.47 plus or minus 0.02 m/s; laminectomy-only sham
bpV(pic) alone and the combination improved forelimb function and reduced lesion and cavity size, whereas Schwann cells alone reduced cavitation without functional benefit and the combination added little over bpV(pic) except a greater axon-to-lesion ratio.
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