Evidence & regulatory context
- Mechanism
- Not recorded
- Target
- Not recorded
- Injury models
- Spinal cord injury
- Reported indication
- Not recorded
- First approval
- Not recorded
- Development stage
- Not recorded
- ChEMBL record
- Not recorded
- ChEMBL max phase
- Not recorded
- Synonyms
- Not recorded
- Note
- Not recorded
Clinical trials 0
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
No linked human trial in this dataset.
Preclinical evidence 2
2 studies reported at therapy level; 2 evidence entries itemised.
RatSpinal cord injuryContusionSprague-Dawley (GFP-expressing transgenic Sprague-Dawley donors for Schwann cells)Femalen = 34 rats allocated: sham 6, vehicle 6, bpV 6, Schwann cells…bpV(pic) intraperitoneal; Schwann cells stereotaxic intraspinal injection into the lesion epicentre at 1.2 mm depth400 micrograms/kg/day bpV(pic) stated in the methods (the a…bpV(pic) immediately after injury and at 2 hours; Schwann cells transplanted 7…
Model: Right unilateral C5 hemicontusion using the NYU/MASCIS impactor, 2.5 mm tip, 10 g weight, 12.5 mm drop height, measured displacement 2.02 plus or minus 0.21 mm and velocity 0.47 plus or minus 0.02 m/s; laminectomy-only sham
bpV(pic) alone and the combination improved forelimb function and reduced lesion and cavity size, whereas Schwann cells alone reduced cavitation without functional benefit and the combination added little over bpV(pic) except a greater axon-to-lesion ratio.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.
RatSpinal cord injuryContusionSprague-Dawley (Harlan)femalen = n = 19 rats total: sham n = 3, vehicle n = 8, bpV n = 8intraperitoneal200 microgram/kg per injection in 0.9% saline, giving 400 m…immediately after injury, with a second dose at 2 hours post-injury
Model: Unilateral cervical hemicontusion spinal cord injury using the NYU/MASCIS impactor (2.5 mm tip, 10 g weight dropped from 12.5 mm) producing a moderate unilateral injury; anaesthesia ketamine 87 mg/kg with xylazine 12 mg/kg intraperitoneally
bpV(pic) significantly increased spared white matter (30%, p < 0.01) and Luxol Fast Blue myelin area rostrally (0.64 +/- 0.02 versus vehicle 0.56 +/- 0.01, p < 0.05) and at the epicentre (0.54 +/- 0.03 versus vehicle 0.42 +/- 0.03, p < 0.05). Ventrolateral funiculus oligodendrocyte density rose to…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.95. Machine-extracted fields require source verification.
