N-acetyl cysteine improves the effects of corticosteroids in a mouse model of chlorine-induced acute lung injury.
MouseChemical/toxinBALB/cFemaleTreatments administered 1 hour after chlorine exposure
Model: Inhalation exposure to 300 ppm chlorine gas for 15 minutes
Neither N-acetyl cysteine nor dexamethasone alone reduced airway hyperreactivity, but the combination protected against airway hyperreactivity and significantly reduced neutrophil influx, while triptolide, reparixin and rolipram did not alter airway hyperreactivity.
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