Pulsed radiofrequency inhibited activation of spinal mitogen-activated protein kinases and ameliorated early neuropathic pain in rats.
RatOtherSprague-DawleyMaleApplied after nerve injury as an early treatment
Model: L5 spinal nerve ligation producing peripheral nerve injury and neuropathic pain
Pulsed radiofrequency attenuated mechanical allodynia and thermal hyperalgesia for 5 to 7 days and suppressed spinal ERK and p38 activation and TNF-alpha expression.
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