THERAPY DOSSIER · th-f042a5d268f3

Low-volt pulsed radiofrequency applied to the L5 dorsal root ganglion

Procedure · Procedure (pulsed radiofrequency to the dorsal root ganglion); not a ChEMBL entity

Evidence & regulatory context

Mechanism: Procedure (pulsed radiofrequency to the dorsal root ganglion); not a ChEMBL entity
Target: Not recorded
Injury models: Other
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 2

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT06711419 ↗NAnot yet recruiting

Caudal Neuroplasty Combined With Pulsed Radiofrequency Targeting the Dorsal Root Ganglion in Lumbosacral Radicular Pain

Disc Herniation

Enrolment: 70 · Results not recorded

NCT04209322 ↗NAcompleted

Pulsed Radiofrequency for Sciatica and Disc Herniation

Sciatica

Enrolment: 250 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 25493301 ↗2014Reported benefit

Pulsed radiofrequency inhibited activation of spinal mitogen-activated protein kinases and ameliorated early neuropathic pain in rats.

RatOtherSprague-DawleyMaleApplied after nerve injury as an early treatment

Model: L5 spinal nerve ligation producing peripheral nerve injury and neuropathic pain

Pulsed radiofrequency attenuated mechanical allodynia and thermal hyperalgesia for 5 to 7 days and suppressed spinal ERK and p38 activation and TNF-alpha expression.

Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.

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