Pirfenidone prevents rat esophageal stricture formation.
RatChemical/toxinWistarMaleAdministered as an 8% gel (route of administration not further specified in the abstract)200 mg/kg/dayFrom the acute phase after caustic injury
Model: Caustic oesophageal burn produced by application of 32% sodium hydroxide to the distal oesophagus
Pirfenidone reduced endoscopic and radiographic stenosis and collagen deposition and lowered profibrogenic gene expression, with MMP-2 unchanged.
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